035 CD59 Blood Group
The CD59 blood group system consists of 1 antigen carried on a 20 kDa glycosylphosphatidylinositol (GPI) linked glycoprotein (CD59). It consists of 128 amino acids and has a signal sequence of 25 amino acids. Another 26 amino acids are removed from the C-terminal end of mature protein which consists of 77 amino acids.
Reference Info
Gene: CD59
Allele: CD59*01
Seq: NG_008057.1
(genomic), NM_203330.2 (transcript)
Entrez GeneID: 966
Number of exons: 6
Allele: CD59*01
Seq: NG_008057.1
(genomic), NM_203330.2 (transcript)
Entrez GeneID: 966
Number of exons: 6
| Loading Data ... |
| allele_category | Phenotype | Allele Name | Nucleotide Changes |
Exon | Amino Acid Changes |
hg38 | gnomAD | rsNum | GenBank | Reference |
|---|---|---|---|---|---|---|---|---|---|---|
| 0:Antigen Alleles | CD59:+1 or CD59.1+ | CD59*01 | ||||||||
| 4:Null Alleles | CD59:-1 or CD59.1- | CD59*01N.01 | c.146delA | Exon 5 | p.Asp49Valfs*31 | chr11:33717393 |
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| 4:Null Alleles | CD59:-1 or CD59.1- | CD59*01N.02 |
c.123delC c.361delG |
Exon 5
Exon 6 |
p.Val42Serfs*38 not applicable |
chr11:33717416 chr11:33710152 |
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| 4:Null Alleles | CD59:-1 or CD59.1- | CD59*01N.03 | c.266G>A | Exon 6 | p.Cys89Tyr | chr11:33710247 |
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| 0:Antigen Alleles | CD59:-1 or CD59.1- | CD59*02† | c.146A>T | Exon 5 | p.Asp49Val | chr11:33717393 |
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| 0:Antigen Alleles | CD59:+1 or CD59.1+ | CD59*03† | c.238A>G | Exon 6 | p.Arg80Gly | chr11:33710275 |
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