Blood Group Database

008 Duffy Blood Group

The Duffy blood group system consists of five antigens carried on a multipass membrane glycoprotein called the Duffy Antigen Receptor for Chemokines (aka DARC, CD234). It consists of 336 (major) and 338 (minor) amino acids. The major transcript is derived from exon 1 and exon 2 of FY; the minor product is a transcript initiated at the beginning of exon 2. The amino terminus is predicted to be extracellular and the carboxyl terminus intracellular.

Antigens

[1] Fya

[2] Fyb

[3] Fy3

[4] …

[5] Fy5

[6] Fy6

Reference Info

Gene: ACKR1
Allele: FY*02. Acceptable: FY*B
Seq: NG_011626.2

(genomic), NM_002036.3

(transcript)
Entrez GeneID: 2532

Number of exons: 2

ACKR1

Loading Data ...

allele_category	Phenotype	Allele Name	Nucleotide Changes	Exon	Amino Acid Changes	hg38	rsNum	GenBank
0:Antigen Alleles	FY:1 or Fy(a+)	FY01 or FYA	c.125A>G	Exon 2	p.Asp42Gly	chr1:159205564
4:Null Alleles	Fy(a-b-) erythroid cells only‡	FY01N.01*	c.-67T>C	Exon 1	p.0	chr1:159204893	rs2814778
4:Null Alleles	Fy(a-b-)	FY01N.02*	c.286_299del	Exon 2	p.Trp96_Thrfs*22	chr1:159205725
4:Null Alleles	Fy(a-b-)	FY01N.03*	c.408G>A	Exon 2	p.Trp136*	chr1:159205847
4:Null Alleles	Fy(a-b-)	FY01N.04*	c.287G>A	Exon 2	p.Trp96Ter	chr1:159205726	rs750052723
4:Null Alleles	Fy(a-b-)	FY01N.05*	c.327delC	Exon 2	p.Phe109Leufs*12	chr1:159205766
4:Null Alleles	Fy(a-b-)	FY01N.06*	c.395G>A	Exon 2	p.Gly132Asp	chr1:159205834	rs530992295
4:Null Alleles	Fy(a-b-)	FY01N.07*	c.719delG	Exon 2	p.Gly240Alafs*4	chr1:159206158
4:Null Alleles	Fy(a-b-) erythroid cells only	FY01N.08*	c.-69T>C	Exon 1	p.0	chr1:159204891
4:Null Alleles	Fy(a-b-)	FY01N.09*	c.296_496delinsAGGCCACTG	Exon 2	p.Leu99_Leu165delinsGlnAlaThrAla	chr1:159205735
4:Null Alleles	Fy(a−b−)	FY01N.10*	c.762G>A	Exon 2	p.Trp254Ter	chr1:159206201	rs766558424
4:Null Alleles	Fy(a−b−)	FY01N.11*	c.854delT	Exon 2	p.Leu285Argfs*2	chr1:159206293	rs763701958
1:Weak Alleles	Fy(a+w)	FY01W.01*	c.265C>T	Exon 2	p.Arg89Cys	chr1:159205704	rs34599082	KU726825
1:Weak Alleles	Fy(a+w)	FY01W.02*	c.265C>T c.298G>A	Exon 2 Exon 2	p.Arg89Cys p.Ala100Thr	chr1:159205704 chr1:159205737	rs34599082 rs13962
1:Weak Alleles	Fy(a+w)	FY01W.03*	c.680G>A	Exon 2	p.Gly227Glu	chr1:159206119	rs758564844
0:Antigen Alleles	FY:2 or Fy(b+)	FY02 or FYB	c.125G>A	Exon 2	p.Gly42Asp	chr1:159205564	rs12075
0:Antigen Alleles	FY:-2,3	FY02.01*	c.126T>G	Exon 2	p.Gly42Glu	chr1:159205565
4:Null Alleles	Fy(a-b-) erythroid cells only	FY02N.01*	c.-67T>C	Exon 1	p.0	chr1:159204893	rs2814778
4:Null Alleles	Fy(a-b-)	FY02N.02*	c.407G>A	Exon 2	p.Trp136Ter	chr1:159205846	rs76819093
4:Null Alleles	Fy(a-b-)	FY02N.03*	c.781G>A	Exon 2	p.Gly261Arg	chr1:159206220
4:Null Alleles	Fy(a-b-)	FY02N.04*	c.179_180delCT	Exon 2	p.Ser60Cysfs*16	chr1:159205618
4:Null Alleles	Fy(a-b-)	FY02N.05*	c.895G>A	Exon 2	p.Ala299Thr	chr1:159206334	rs752428245
4:Null Alleles	Fy(a-b-)	FY02N.06*	c.151delT	Exon 2	p.Cys51Alafs*24	chr1:159205590
4:Null Alleles	Fy(a−b−)	FY02N.07*	c.124delG	Exon 2	p.Asp42Metfs*33	chr1:159205563
4:Null Alleles	Fy(a−b−)	FY02N.08*	c.400delT	Exon 2	p.Cys134Valfs*14	chr1:159205839
1:Weak Alleles	Fy(b+w), Fyx	FY02W.01*	c.265C>T c.298G>A	Exon 2 Exon 2	p.Arg89Cys p.Ala100Thr	chr1:159205704 chr1:159205737	rs34599082 rs13962
1:Weak Alleles	Fy(b+w), Fyx	FY02W.02*	c.145G>T c.265C>T c.298G>A	Exon 2 Exon 2 Exon 2	p.Ala49Ser p.Arg89Cys p.Ala100Thr	chr1:159205584 chr1:159205704 chr1:159205737	rs1307925062 rs34599082 rs13962
1:Weak Alleles	Fy(b+w)	FY02W.03*	c.266G>A	Exon 2	p.Arg89His	chr1:159205705	rs371909350
1:Weak Alleles	Fy(b+w)	FY02W.04*	c.901C>T	Exon 2	p.Pro301Ser	chr1:159206340	rs753831902
1:Weak Alleles	Fy(b+w)	FY02W.05*	c.976C>T	Exon 2	p.Ser326Phe	chr1:159206415