Blood Group Database

020 Gerbich Blood Group

The Gerbich blood group system consists of 11 antigens carried on a single pass type I membrane glycoprotein with called glycophorin C (GPC) and/or glycophorin D (GPD). GPC consists of 128 amino acids and GPD, the shorter isoform, has 107 amino acids. The glycoproteins are encoded by GYPC, or GE if analysis is to predict a blood group antigen.

Antigens

[1] …

[2] Ge2

[3] Ge3

[4] Ge4

[5] Wb

[6] Lsa

[7] Ana

[8] Dha

[9] GEIS

[10] GEPL

[11] GEAT

[12] GETI

Reference Info

Gene: GYPC
Allele: GE*01. Acceptable: Ge if inferred by haemagglutination
Seq: NG_007479.1

(genomic), NM_002101.4

(transcript)
Entrez GeneID: 2995

Number of exons: 4

GYPC

Loading Data ...

allele_category	Phenotype	Allele Name	Nucleotide Changes	Exon	Amino Acid Changes	hg38	rsNum
0:Antigen Alleles	GE:2,3,4	GE01*
0:Antigen Alleles	Ge:-2,3,4 or Yus type	GE01.-02*	del Exon 2		in frame deletion
0:Antigen Alleles	Ge:-2,3,4 or Yus type	GE01.-02.01*	NG_007479.1: g.39158_42766del c.60_116del		p.(Ala23_Met41del)
0:Antigen Alleles		GE01.-02.02*	NG_007479.1: g.37523_41132del c.50- 1625_107-1625del		p.(Glu17_Ala35del)
0:Antigen Alleles		GE01.-02.03*	NG_007479.1: g.38410_42021del c.50- 738_107-736del		p.(Glu17_Ala35del)
0:Antigen Alleles		GE01.-02.04*	NG_007479.1: g.37342_40948del c.50- 1806_106+1744del		p.(Glu17_Ala35del)
0:Antigen Alleles	GE:-2,-3,4 or Gerbich type	GE01.-03*	del Exon 3		in frame deletion
0:Antigen Alleles	GE:-2,-3,4 or Gerbich type	GE01.-03.01*	NG_007479.1: g.40492_44103del c.106+1288_191-736del		p.(Glu36_Ala63del)
0:Antigen Alleles		GE01.-03.02*	NG_007479.1: g.40117_43777del c.106+913_190+937del		p.(Glu36_Ala63del)
0:Antigen Alleles		GE01.-03.03*	NG_007479.1: g.39347_42996del c.106+143_190+156del		p.(Glu36_Ala63del)
0:Antigen Alleles	GE:-10 or GEPL-	GE01.-10*	c.134C>T	Exon 3	p.Pro45Leu in GPC, p.Pro24Leu in GPD	chr2:126693891	rs139780142
0:Antigen Alleles	GE :-11 or GEAT-	GE01.-11*	c.56A>T	Exon 2	p.Asp19Val in GPC	chr2:126690261	rs749522569
0:Antigen Alleles	GE:-12 or GETI-	GE01.-12*	c.80C>T	Exon 2	p.Thr27Ile in GPC, p.Thr6Ile in GPD	chr2:126690285	rs776682317
0:Antigen Alleles	GE:5 or Wb+	GE01.05*	c.23A>G	Exon 1	p.Asn8Ser in GPC	chr2:126656286	rs121912760
0:Antigen Alleles	GE:6 or Ls(a+)	GE01.06.01*	Duplicated Exon 3		in frame duplication
0:Antigen Alleles	GE:6 or Ls(a+)	GE01.06.02*	Triplicated Exon 3		in frame triplication
0:Antigen Alleles	GE:7 or An(a+)	GE01.07*	c.67G>T	Exon 2	p.Ala23Ser in GPC, p.Ala2Ser in GPD ‡	chr2:126690272	rs774359594
0:Antigen Alleles	GE:8 or Dh(a+)	GE01.08*	c.40C>T	Exon 1	p.Leu14Phe in GPC	chr2:126656303	rs121912761
0:Antigen Alleles	GE:9 or GEIS+	GE01.09*	c.95C>A	Exon 2	p.Thr32Asn in GPC, p.Thr11Asn in GPD	chr2:126690300
4:Null Alleles	Ge:-2,-3,-4 Leach type (PL)	GE01N.01*	del Exons 3 & 4
4:Null Alleles	Ge:-2,-3,-4 Leach type (LN)	GE01N.02*	c.131G>T c.134delC	Exon 3 Exon 3	p.Trp44Leu p.Pro45Argfs*12	chr2:126693888 chr2:126693891