023 IN Blood Group
The IN blood group system consists of 4 antigens carried on a glycoprotein (CD44) of 361 amino acids. It has a leader sequence of 20 amino acids that is sometimes cleaved. The protein is found in many different tissues and multiple tissue-specific isoforms of CD44 exist. The haemopoietic form is approximately 80kDa and encoded by exons 1-5, 15-17, 19.
Reference Info
Gene: CD44
Allele: IN*02. Acceptable: IN*B, or Inb if inferred by haemagglutination
Seq: NG_008937.1
(genomic), NM_001001391.1 (transcript)
Entrez GeneID: 960
Number of exons: 19
Allele: IN*02. Acceptable: IN*B, or Inb if inferred by haemagglutination
Seq: NG_008937.1
(genomic), NM_001001391.1 (transcript)
Entrez GeneID: 960
Number of exons: 19
| Loading Data ... |
| allele_category | Phenotype | Allele Name | Nucleotide Changes |
Exon | Amino Acid Changes |
hg38 | gnomAD | rsNum | GenBank | Reference |
|---|---|---|---|---|---|---|---|---|---|---|
| 0:Antigen Alleles | In(a+b-) | IN*01 or IN*A | c.137G>C | Exon 2 | p.Arg46Pro | chr11:35176644 |
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| 0:Antigen Alleles | In(a-b+) | IN*02 or IN*B | ||||||||
| 0:Antigen Alleles | IN:-3 or INFI- | IN*02.-03 | c.255C>G | Exon 3 | p.His85Gln | chr11:35180295 |
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| 0:Antigen Alleles | IN:-4 or INJA- | IN*02.-04 | c.488C>A | Exon 5 | p.Thr163Lys | chr11:35189886 |
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| 0:Antigen Alleles | IN: -5 or INRA- | IN*02.-05 | c.449G>A | Exon 5 | p.Arg150His | chr11:35189847 |
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| 0:Antigen Alleles | IN: -6 or INSL- | IN*02.-06 | c.276C>A | Exon 3 | p.His92Gln | chr11:35180316 |
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