Blood Group Database

006 Kell Blood Group

The Kell blood group system consists of 32 antigens carried on a type II glycoprotein (aka CD238) of 732 amino acids. The Kell glycoprotein is a zinc-dependent metalloproteinase that has been shown to have endothelin-3-converting activity.

Antigens

[1] K

[2] k

[3] Kpa

[4] Kpb

[5] Ku

[6] Jsa

[7] Jsb

[8] …

[9] …

[10] Ula

[11] K11

[12] K12

[13] K13

[14] K14

[15] …

[16] K16

[17] K17

[18] K18

[19] K19

[20] Km

[21] Kpc

[22] K22

[23] K23

[24] K24

[25] VLAN

[26] TOU

[27] RAZ

[28] VONG

[29] KALT

[30] KTIM

[31] KYO

[32] KUCI

[33] KANT

[34] KASH

[35] KELP

[36] KETI

[37] KHUL

[38] KYOR

[39] KEAL

Reference Info

Gene: KEL
Allele: KEL*02. Acceptable: k if inferred by haemagglutination
Seq: NG_007492.1

(genomic), NM_000420.2

(transcript)
Entrez GeneID: 3792

Number of exons: 19

KEL

Loading Data ...

allele_category	Phenotype	Allele Name	Nucleotide Changes	Exon	Amino Acid Changes	hg38	rsNum	GenBank	Reference
0:Antigen Alleles	KEL:1,−2 or K+ k−	KEL01.01*	c.578C>T	Exon 6	p.Thr193Met	chr7:142957921	rs8176058	S76770	7849312
0:Antigen Alleles	KEL:1weak or K+w	KEL01.02*	c.577A>T	Exon 6	p.Thr193Ser	chr7:142957922	rs61729031		17076841
0:Antigen Alleles	KEL:1weak,3 or K+w, Kp(a+)	KEL01.03*	c.578C>T c.841C>T	Exon 6 Exon 8	p.Thr193Met p.Arg281Trp	chr7:142957921 chr7:142954267	rs8176058 rs8176059	FM208212.1	19347978
2:Mod Alleles	K_mod; KEL:1weak	KEL01M.01*	c.578C>G	Exon 6	p.Thr193Arg	chr7:142957921	rs8176058
2:Mod Alleles	K_mod	KEL01M.02*	c.578C>T c.977C>T	Exon 6 Exon 9	p.Thr193Met p.Pro326Leu	chr7:142957921 chr7:142953904	rs8176058 rs751284993
2:Mod Alleles	K_mod	KEL01M.03*	c.578C>T c.1339C>T c.1680A>C	Exon 6 Exon 12 Exon 15	p.Thr193Met p.Arg447Trp p.Pro560Pro	chr7:142957921 chr7:142944717 chr7:142943509	rs8176058 rs142604829 rs8176036
2:Mod Alleles	K_mod	KEL01M.04*	c.578C>T c.1920G>C c.1921G>A	Exon 6 Exon 17 Exon 17	p.Thr193Met p.Gly640Gly p.Gly641Arg	chr7:142957921 chr7:142942896 chr7:142942895	rs8176058
2:Mod Alleles	K_mod	KEL01M.05*	c.578C>T c.1899A>G c.1934C>T	Exon 6 Exon 17 Exon 17	p.Thr193Met p.Leu633Leu p.Ala645Val	chr7:142957921 chr7:142942917 chr7:142942882	rs8176058 rs8176039 rs147851584
2:Mod Alleles	K_mod	KEL01M.06*	c.578C>T c.1680A>C c.2107G>C	Exon 6 Exon 15 Exon 19	p.Thr193Met p.Pro560Pro p.Gly703Arg	chr7:142957921 chr7:142943509 chr7:142941344	rs8176058 rs8176036 rs191330570
4:Null Alleles	K₀	KEL01N.01*	c.578C>T c.1678C>G	Exon 6 Exon 15	p.Thr193Met p.Pro560Ala	chr7:142957921 chr7:142943511	rs8176058 rs61729046
4:Null Alleles	K₀	KEL01N.02*	c.244T>C c.578C>T	Exon 4 Exon 6	p.Cys82Arg p.Thr193Met	chr7:142961084 chr7:142957921	rs369127636 rs8176058
4:Null Alleles	K₀	KEL01N.03*	c.1382_1385del4	Exon 12	p.Asn461Argfs*25	chr7:142944674
0:Antigen Alleles	KEL:2 or k+	KEL02*						NM_000420.2	1712490
0:Antigen Alleles	KEL: -12	KEL02.-12*	c.1643A>G	Exon 15	p.His548Arg	chr7:142943546	rs61729033
0:Antigen Alleles	KEL:-14,-24	KEL02.-14.1*	c.538C>T	Exon 6	p.Arg180Cys	chr7:142957961	rs747437444
0:Antigen Alleles	KEL:-14	KEL02.-14.2*	c.539G>A	Exon 6	p.Arg180His	chr7:142957960	rs61729039
0:Antigen Alleles	KEL:-18	KEL02.-18.1*	c.388C>T	Exon 4	p.Arg130Trp	chr7:142960940	rs184131044
0:Antigen Alleles	KEL:-18	KEL02.-18.2*	c.389G>A	Exon 4	p.Arg130Gln	chr7:142960939	rs201110152
0:Antigen Alleles	KEL:-19	KEL02.-19*	c.1475G>A	Exon 13	p.Arg492Gln	chr7:142944339	rs61729035
0:Antigen Alleles	KEL:-22	KEL02.-22*	c.965C>T	Exon 9	p.Ala322Val	chr7:142953916	rs61729037
0:Antigen Alleles	KEL:-26	KEL02.-26*	c.1217G>A	Exon 11	p.Arg406Gln	chr7:142946304	rs61729041
0:Antigen Alleles	KEL:-27	KEL02.-27*	c.745G>A	Exon 8	p.Glu249Lys	chr7:142954363	rs61729042
0:Antigen Alleles	KEL:-29	KEL02.-29*	c.1868G>A	Exon 17	p.Arg623Lys	chr7:142942948	rs61729043
0:Antigen Alleles	KEL:-30	KEL02.-30*	c.913G>A	Exon 8	p.Asp305Asn	chr7:142954195	rs61729044
0:Antigen Alleles	KEL:-32	KEL02.-32*	c.1271C>T	Exon 11	p.Ala424Val	chr7:142946250	rs779011501
0:Antigen Alleles	KEL:-33	KEL02.-33*	c.1283G>T	Exon 11	p.Arg428Leu	chr7:142946238	rs750806448
0:Antigen Alleles	KEL:-34	KEL02.-34*	c.758A>G	Exon 8	p.Tyr253Cys	chr7:142954350
0:Antigen Alleles	KEL:-35	KEL02.-35*	c.780G>T c.2024G>A	Exon 8 Exon 18	p.Leu260Phe p.Arg675Gln	chr7:142954328 chr7:142942447	rs760716472
0:Antigen Alleles	KEL:-36	KEL02.-36*	c.1391C>T	Exon 12	p.Thr464Ile	chr7:142944665	rs190890637
0:Antigen Alleles	KEL:-37	KEL02.-37*	c.877C>T	Exon 8	p.Arg293Trp	chr7:142954231	rs557358978
0:Antigen Alleles	KEL:3,−4,−21 or Kp(a+b-c-)	KEL02.03*	c.841C>T	Exon 8	p.Arg281Trp	chr7:142954267	rs8176059	AM085119	8669078
0:Antigen Alleles	KEL:6,-7 or Js(a+b-)	KEL02.06*	c.1790T>C	Exon 17	p.Leu597Pro	chr7:142943026	rs8176038
0:Antigen Alleles	KEL:10	KEL02.10*	c.1481A>T	Exon 13	p.Glu494Val	chr7:142944333	rs61729032
0:Antigen Alleles	KEL: -11,17	KEL02.17*	c.905T>C	Exon 8	p.Val302Ala	chr7:142954203	rs61729034
0:Antigen Alleles	KEL:-3,-4,21 or Kp(a-b-c+)	KEL02.21*	c.842G>A	Exon 8	p.Arg281Gln	chr7:142954266	rs61729036
0:Antigen Alleles	KEL:23	KEL02.23*	c.1145A>G	Exon 10	p.Gln382Arg	chr7:142952567	rs61729038
0:Antigen Alleles	KEL: -14,24	KEL02.24*	c.539G>C	Exon 6	p.Arg180Pro	chr7:142957960	rs61729039
0:Antigen Alleles	KEL:25,-28	KEL02.25*	c.743G>A	Exon 8	p.Arg248Gln	chr7:142954365	rs61729040
0:Antigen Alleles	KEL:-25,28	KEL02.28*	c.742C>T	Exon 8	p.Arg248Trp	chr7:142954366	rs61728832
0:Antigen Alleles	KEL:31,-38	KEL02.31*	c.875G>A	Exon 8	p.Arg292Gln	chr7:142954233	rs201698610
0:Antigen Alleles	KEL:-37,39 or KHUL-,KEAL+	KEL02.39*	c.877C>T	Exon 8	p.Arg293Trp	chr7:142954231	rs557358978
0:Antigen Alleles	KEL:40	KEL02.40*	c.1546C>A	Exon 14	p.Arg516Arg	chr7:142943829	rs8176034
2:Mod Alleles	K_mod	KEL02M.01*	c.1088G>A	Exon 10	p.Ser363Asn	chr7:142952624	rs61729055
2:Mod Alleles	K_mod	KEL02M.02*	c.2030A>G	Exon 18	p.Tyr677Cys	chr7:142942441	rs147464117
2:Mod Alleles	K_mod KEL:-13	KEL02M.03*	c.986T>C	Exon 9	p.Leu329Pro	chr7:142953895	rs61729057
2:Mod Alleles	K_mod	KEL02M.04*	c.2107G>A	Exon 19	p.Gly703Arg	chr7:142941344	rs191330570
2:Mod Alleles	K_mod	KEL02M.05*	c.1719C>T	Exon 16	p.Gly573=	chr7:142943328	rs145850557
2:Mod Alleles	K_mod	KEL02M.06*	c.306C>A c.1298C>T	Exon 4 Exon 11	p.Asp102Glu p.Pro433Leu	chr7:142961022 chr7:142946223	rs143238294
2:Mod Alleles	K_mod	KEL02M.07*	c.1763A>G	Exon 16	p.Tyr588Cys	chr7:142943284	rs61729048
2:Mod Alleles	K_mod	KEL02M.08*	c.1490A>T	Exon 13	p.Asp497Val	chr7:142944324	rs1286534156
2:Mod Alleles	K_mod	KEL02M.09*	c.1757T>G	Exon 16	p.Ile586Ser	chr7:142943290
2:Mod Alleles	K_mod	KEL02M.10*	c.787G>A	Exon 8	p.Gly263Arg	chr7:142954321
2:Mod Alleles	K_mod	KEL02M.11*	c.1268C>T	Exon 11	p.Ala423Val	chr7:142946253	rs61728831
2:Mod Alleles	K_mod	KEL02M.12*	c.2111C>A	Exon 19	p.Pro704His	chr7:142941340	rs747806266
2:Mod Alleles	K_mod	KEL02M.13*	c.257G>A c.841C>T	Exon 4 Exon 8	p.Arg86Gln p.Arg281Trp	chr7:142961071 chr7:142954267	rs777011308 rs8176059
2:Mod Alleles	K_mod	KEL02M.14*	c.1084C>A	Exon 10	p.Gln362Lys	chr7:142952628	rs766310210
2:Mod Alleles	K_mod	KEL02M.15*	c.575G>C	Exon 6	p.Arg192Pro	chr7:142957924	rs754663945
2:Mod Alleles	K_mod	KEL02M.16*	c.788G>A	Exon 8	p.Gly263Glu	chr7:142954320
2:Mod Alleles	K_mod	KEL02M.17*	c.586C>G	Exon 6	p.Leu196Val	chr7:142957913	rs760539605
2:Mod Alleles	K_mod	KEL02M.18*	c.1664G>T	Exon 15	p.Gly555Val	chr7:142943525
4:Null Alleles	K₀	KEL02N.01*	c.223+1G>C	Intron 3	p.Arg75fs*?	chr7:142961359
4:Null Alleles	K₀	KEL02N.02*	c.382C>T c.1790T>C	Exon 4 Exon 17	p.Arg128Ter	chr7:142960946 chr7:142943026	rs61729053 rs8176038
4:Null Alleles	K₀	KEL02N.03*	c.246T>A	Exon 4	p.Cys82*	chr7:142961082	rs61729058
4:Null Alleles	K₀	KEL02N.04*	c.1042C>T	Exon 9	p.Gln348*	chr7:142953839	rs61729054
4:Null Alleles	K₀	KEL02N.05*	c.2027G>A	Exon 18	p.Ser676Asn	chr7:142942444	rs61729051
4:Null Alleles	K₀	KEL02N.06*	c.223+1G>A	Intron 3	p.Arg75fs	chr7:142961359	rs369569464
4:Null Alleles	K₀	KEL02N.07*	c.574C>T	Exon 6	p.Arg192*	chr7:142957925	rs200430183
4:Null Alleles	K₀	KEL02N.08*	c.526-2A>G	Intron 5	Alternative splicing	chr7:142957975
4:Null Alleles	K₀	KEL02N.09*	c.1377G>A	Exon 12	p.Trp459*	chr7:142944679	rs61729052
4:Null Alleles	K₀	KEL02N.10*	c.1420C>T	Exon 13	p.Gln474*	chr7:142944394	rs61729056
4:Null Alleles	K₀	KEL02N.11*	c.904delG	Exon 8	p.Val302Serfs*28	chr7:142954204	rs61729059
4:Null Alleles	K₀	KEL02N.12*	c.924+1G>A	Intron 8	Alternative splicing	chr7:142954183	rs568600999
4:Null Alleles	K₀	KEL02N.13*	c.924+1G>T	Intron 8	Alternative splicing	chr7:142954183	rs568600999
4:Null Alleles	K₀	KEL02N.14*	c.948G>A	Exon 9	p.Trp316*	chr7:142953933	rs61729049		17381630
4:Null Alleles	K₀	KEL02N.15*	c.1216C>T	Exon 11	p.Arg406*	chr7:142946305	rs61729045		17381630
4:Null Alleles	K₀	KEL02N.16*	c.1477C>T	Exon 13	p.Gln493*	chr7:142944337	rs61729050
4:Null Alleles	K₀	KEL02N.17*	c.1546C>T	Exon 14	p.Arg516*	chr7:142943829	rs8176034
4:Null Alleles	K₀	KEL02N.18*	c.1678C>G	Exon 15	p.Pro560Ala	chr7:142943511	rs61729046
4:Null Alleles	K₀	KEL02N.19*	c.2023C>T	Exon 18	p.Arg675*	chr7:142942448	rs61729047
4:Null Alleles	K₀	KEL02N.20*	c.1596G>A	Exon 15	p.Trp532*	chr7:142943593
4:Null Alleles	K₀	KEL02N.21*	c.1947C>G	Exon 18	p.Tyr649*	chr7:142942524	rs902425813
4:Null Alleles	K₀	KEL02N.22*	c.736-1G>C	Intron 7	Alternative splicing	chr7:142954373	rs765075509
4:Null Alleles	K₀	KEL02N.23*	c.184dupT	Exon 3	p.Ser62Phefs*17	chr7:142961399	rs751207765
4:Null Alleles	K₀	KEL02N.24*	c.715G>T	Exon 7	p.Glu239*	chr7:142954485	rs766427535
4:Null Alleles	K₀	KEL02N.25*	c.1975delG	Exon 18	p.Glu659Argfs*22	chr7:142942496	rs1042359399
4:Null Alleles	K₀	KEL02N.26*	c.382C>T	Exon 4	p.Arg128*	chr7:142960946	rs61729053
4:Null Alleles	K₀	KEL02N.27*	c.730delG	Exon 7	p.Ala244Profs*8	chr7:142954470
4:Null Alleles	K₀	KEL02N.28*	c.230G>T	Exon 4	p.Cys77Phe	chr7:142961098
4:Null Alleles	K₀	KEL02N.29*	c.1664G>A	Exon 15	p.Gly555Glu	chr7:142943525
4:Null Alleles	K₀	KEL02N.30*	c.71G>A	Exon 2	p.Trp24*	chr7:142961805	rs753369164
4:Null Alleles	K₀	KEL02N.31*	c.1771+1g>a	Intron 16	Aberrant splicing	chr7:142943275	rs869025768
4:Null Alleles	K₀	KEL02N.32*	c.455A>G	Exon 5	p.Tyr152Cys	chr7:142958374
4:Null Alleles	K₀	KEL02N.33*	c.1726G>C	Exon 16	p.Gly576Arg	chr7:142943321	rs201778033
4:Null Alleles	K₀	KEL02N.34*	c.841C>T c.2099G>A	Exon 8 Exon 19	p.Arg281Trp p.Arg700Gln	chr7:142954267 chr7:142941352	rs8176059 rs1268359042
4:Null Alleles	K₀	KEL02N.35*	c.398T>C	Exon 4	p.Leu133Pro	chr7:142960930
4:Null Alleles	K₀	KEL02N.36*	c.436delG	Exon 5	p.Glu146Argfs*43	chr7:142958393	rs1562964425
4:Null Alleles	K₀	KEL02N.37*	c.1253T>C	Exon 11	p.Phe418Ser	chr7:142946268	rs149225200
4:Null Alleles	K₀	KEL02N.38*	c.1832T>G	Exon 17	p.Leu611Arg	chr7:142942984
4:Null Alleles	K₀	KEL02N.39*	c.2098C>T	Exon 19	p.Arg700*	chr7:142941353	rs565926203
4:Null Alleles	K₀	KEL02N.40*	c.1474C>T	Exon 13	p.Arg492*	chr7:142944340	rs932456335
4:Null Alleles	K₀	KEL02N.41*	c.267C>G	Exon 4	p.Tyr89*	chr7:142961061	rs879327552
4:Null Alleles	K₀	KEL02N.42*	c.299G>C	Exon 4	p.Cys100Ser	chr7:142961029	rs200268316
4:Null Alleles	K₀	KEL02N.43*	c.328delA	Exon 4	p.Arg110Glyfs*79	chr7:142961000
4:Null Alleles	K₀	KEL02N.44*	c.2175delC	Exon 19	p.Ser726Profs*43	chr7:142941276
4:Null Alleles	K₀	KEL02N.45*	c.937G>A c.1073G>C	Exon 9 Exon 9	p.Ala313Thr p.Arg358Thr	chr7:142953944 chr7:142953808	rs191311545
4:Null Alleles	K₀	KEL02N.46*	c.160_161delATinsCTCC	Exon 3	p.Ile54Leufs*136	chr7:142961423
4:Null Alleles	K₀	KEL02N.47*	c.1664G>T	Exon 15	p.Gly555Val	chr7:142943525
4:Null Alleles	K₀	KEL02N.48*	c.481A>T	Exon 5	p.Ile161Phe	chr7:142958348
4:Null Alleles	K₀	KEL02N.49*	c.997C>T	Exon 9	p.Gln333*	chr7:142953884
4:Null Alleles	K₀	KEL02N.50*	c.2120delG	Exon 19	p.Ser707Thrfs*17	chr7:142941331
4:Null Alleles	K₀	KEL02N.51*	c.1414-1G>C	Intron 12	Aberrant splicing	chr7:142944401
4:Null Alleles	K₀	KEL02N.52*	c.1813_1814insC	Exon 17	p.Gln605Profs*18	chr7:142943003
4:Null Alleles	K₀	KEL02N.53*	c.371delA	Exon 4	p.Lys124Argfs*65	chr7:142960957
4:Null Alleles	K₀	KEL02N.54*	c.201C>A	Exon 3	p.Tyr67*	chr7:142961382
0:Antigen Alleles	KEL:3,−4,−21 or Kp(a+b-c-)	KELTEST_TEST*	c.841C>T	Exon 8	p.Arg281Trp	chr7:142954267	rs8176059		7858266 , 16934067 , 30765865