016 LW Blood Group
The LW blood group system consists of three antigens carried on a glycoprotein of 241 amino acids, ICAM-4, which belongs to the ICAM family of proteins. It has a leader sequence of 30 amino acids, and two I-set IgSF domains that characteristic of this family.
Reference Info
Gene: ICAM4
Allele: LW*05. Acceptable: LW*A, or LWa if inferred by haemagglutination
Seq: NG_007728.1
(genomic), NM_001544.4 (transcript)
Entrez GeneID: 3386
Number of exons: 3
Allele: LW*05. Acceptable: LW*A, or LWa if inferred by haemagglutination
Seq: NG_007728.1
(genomic), NM_001544.4 (transcript)
Entrez GeneID: 3386
Number of exons: 3
| Loading Data ... |
| allele_category | Phenotype | Allele Name | Nucleotide Changes |
Exon | Amino Acid Changes |
hg38 | gnomAD | rsNum | GenBank | Reference |
|---|---|---|---|---|---|---|---|---|---|---|
| 0:Antigen Alleles | LW:5 or LW(a+) | LW*05 or LW*A | ||||||||
| 4:Null Alleles | LW:-6 or LW(a-b-) | LW*05N.01 | c.346_355del | Exon 1 | p.Thr116Glufs*19 | chr19:10287358 |
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| 0:Antigen Alleles | LW:7 or LW(b+) | LW*07 or LW*B | c.299A>G | Exon 1 | p.Gln100Arg | chr19:10287311 |
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