Blood Group Database

005 Lutheran Blood Group

The Lutheran blood group system consists of 22 antigens carried on a single pass type 1 membrane glycoprotein (aka CD239, BCAM) with five disulfide-bonded, extracellular, immunoglobulin superfamily (IgSF) domains, which has adhesion properties and may mediate intracellular signalling. It consists of 597 amino acids.

Antigens

[1] Lua

[2] Lub

[3] Lu3

[4] Lu4

[5] Lu5

[6] Lu6

[7] Lu7

[8] Lu8

[9] Lu9

[10] …

[11] Lu11

[12] Lu12

[13] Lu13

[14] Lu14

[15] …

[16] Lu16

[17] Lu17

[18] Aua

[19] Aub

[20] Lu20

[21] Lu21

[22] LURC

[23] LUIT

[24] LUGA

[25] LUAC

[26] LUBI

[27] LUYA

Reference Info

Gene: BCAM
Allele: LU*02. Acceptable: LU*B, or Lub if inferred by haemagglutination
Seq: NG_007480.1

(genomic), NM_005581.4

(transcript)
Entrez GeneID: 4059

Number of exons: 15

BCAM

Loading Data ...

allele_category	Phenotype	Allele Name	Nucleotide Changes	Exon	Amino Acid Changes	hg38	rsNum	GenBank
1:Weak Alleles	Lu(b+w )	LU02W.01*	c.559C>T c.711C>T c.714C>T	Exon 5 Exon 6 Exon 6	p.Arg187Cys p.Cys237Cys p.Ala238Ala	chr19:44813304 chr19:44813547 chr19:44813550	rs780286955 rs3810141 rs3810140
4:Null Alleles	Lu_null	LU02N.01*	c.691C>T	Exon 6	p.Arg231Ter	chr19:44813527	rs121918132
0:Antigen Alleles	LU:1 or Lu(a+)	LU01 or LUA	c.230G>A	Exon 3	p.Arg77His	chr19:44812188	rs28399653
4:Null Alleles	Lu_null	LU02N.02*	c.204+323_504+183del	Intron 2	p.Thr69_Glu168del	chr19:44811669
0:Antigen Alleles	LU:2 or Lu(b+)	LU02 or LUB
1:Weak Alleles	Lu(b+w ) comment: similarity to LU*02.14	LU02W.02*	c.611T>A c.638C>T	Exon 6 Exon 6	p.Met204Lys p.Ser213Leu	chr19:44813447 chr19:44813474	rs28399656
4:Null Alleles	Lu_null	LU02N.03*	c.711C>A	Exon 6	p.Cys237Ter	chr19:44813547	rs3810141
1:Weak Alleles	Lu(b+w ) comment: similarity to LU*02.-13	LU02W.03*	c.1306C>T c.1340C>T c.1671C>T c.1742A>T	Exon 10 Exon 11 Exon 13 Exon 13	p.Arg436Cys p.Ser447Leu p.Ser557Ser p.Gln581Leu	chr19:44818852 chr19:44819059 chr19:44819634 chr19:44819705	rs150798131 rs117737673 rs28399658 rs28399659
4:Null Alleles	Lu_null	LU02N.04*	c.361C>T	Exon 3	p.Arg121Ter	chr19:44812319	rs121918133
0:Antigen Alleles	LU:-4	LU02.-04.1*	c.524G>A	Exon 5	p.Arg175Gln	chr19:44813269	rs141223803
0:Antigen Alleles	LU:-4	LU02.-04.2*	c.524G>T	Exon 5	p.Arg175Leu	chr19:44813269
0:Antigen Alleles	LU:-5	LU02.-05*	c.326G>A	Exon 3	p.Arg109His	chr19:44812284	rs114801603
4:Null Alleles	Lu_null	LU02N.05*	Ins123GG (?)		42Gly-Arg-X (?)
4:Null Alleles	Lu_null	LU02N.06*	del ex 3 to 15, 26933 bp		p.68Leu-X629
4:Null Alleles	Lu_null	LU02N.07*	c.1049del2ins3	Exon 8	p.Leu350GlnfsTer425	chr19:44814731
0:Antigen Alleles	LU:-7	LU02.-07*	c.1274A>C	Exon 10	p.Glu425Ala	chr19:44818820	rs1229944491
0:Antigen Alleles	LU:-6,9	LU02.09*	c.824C>T	Exon 7	p.Ser275Phe	chr19:44814191	rs139610351
0:Antigen Alleles	LU:-12	LU02.-12.1*	c.99_104delGCGCTT	Exon 2	p.Arg34_Leu35del	chr19:44811241
0:Antigen Alleles	LU:-12	LU02.-12.2*	c.419G>A	Exon 3	p.Arg140Gln	chr19:44812377	rs760604448
0:Antigen Alleles	LU:-13	LU02.-13*	c.1340C>T c.1671C>T c.1742A>T	Exon 11 Exon 13 Exon 13	p.Ser447Leu p.Gln581Leu	chr19:44819059 chr19:44819634 chr19:44819705	rs117737673 rs28399658 rs28399659
0:Antigen Alleles	LU:-8,14	LU02.14*	c.611T>A	Exon 6	p.Met204Lys	chr19:44813447	rs28399656
0:Antigen Alleles	LU:-16	LU01.-16*	c.230G>A c.679C>T	Exon 3 Exon 6	p.Arg77His p.Arg227Cys	chr19:44812188 chr19:44813515	rs28399653 rs150474390
0:Antigen Alleles	LU:-17	LU02.-17*	c.340G>A	Exon 3	p.Glu114Lys	chr19:44812298
0:Antigen Alleles	LU:1,19	LU01.19*	c.230G>A c.1615A>G	Exon 3 Exon 12	p.Arg77His p.Thr539Ala	chr19:44812188 chr19:44819487	rs28399653 rs1135062
0:Antigen Alleles	LU:-18,19 or Au(a-b+)	LU02.19*	c.1615A>G	Exon 12	p.Thr539Ala	chr19:44819487	rs1135062
0:Antigen Alleles	LU:-18,19, -8,14	LU02.19.14*	c.611T>A c.1615A>G	Exon 6 Exon 12	p.Met204Lys p.Thr539Ala	chr19:44813447 chr19:44819487	rs28399656 rs1135062
0:Antigen Alleles	LU:-20	LU02.-20*	c.905C>T	Exon 7	p.Thr302Met	chr19:44814272	rs768582759
0:Antigen Alleles	LU:-21	LU02.-21*	c.282C>G	Exon 3	p.Asp94Glu	chr19:44812240
0:Antigen Alleles	LU:-22 LURC	LU02.-22*	c.223C>T	Exon 3	p.Arg75Cys	chr19:44812181	rs570194003
0:Antigen Alleles	LU:-23 LUIT	LU02.-23*	c.469G>A c.1289C>T	Exon 4 Exon 10	p.Gly157Arg p.Thr430Ile	chr19:44812513 chr19:44818835	rs763826249
0:Antigen Alleles	LU:-24 LUGA	LU02.-24*	c.212G>A c.711C>T c.714C>T	Exon 3 Exon 6 Exon 6	p.Arg71His	chr19:44812170 chr19:44813547 chr19:44813550	rs763340461 rs3810141 rs3810140
0:Antigen Alleles	LU:-25 LUAC	LU02.-25*	c.662C>T	Exon 6	p.Thr221Ile	chr19:44813498
0:Antigen Alleles	LU:-26 LUBI	LU02.-26*	c.1495C>T	Exon 12	p.Arg499Trp	chr19:44819367	rs148391498	FN555134
0:Antigen Alleles	LU:-27, LUYA-	LU02.-27*	c.324G>A c.1184G>A	Exon 3 Exon 9	p.Gly108Gly p.Arg395His	chr19:44812282 chr19:44818627	rs3745159 rs200421757
0:Antigen Alleles	LU:-28, LUNU-	LU02.-28*	c.121G>A	Exon 2	p.Val41Met	chr19:44811263	rs957795435
0:Antigen Alleles	LU:-29, LURA-	LU02.-29*	c.1351A>C	Exon 11	p.Lys451Gln	chr19:44819070	rs28399630